Growth differentiation factor-9 has divergent effects on proliferation and steroidogenesis of bovine granulosa cells
نویسندگان
چکیده
منابع مشابه
Effects of fibroblast growth factor 9 on steroidogenesis and control of FGFR2IIIc mRNA in porcine granulosa cells.
The objectives of this study were to investigate the effects of fibroblast growth factor 9 (FGF9) on hormone-stimulated porcine granulosa cell proliferation and steroid production and to further elucidate the hormonal and developmental control of FGFR2IIIc gene expression in granulosa cells. Porcine ovaries were collected from a local slaughterhouse and granulosa cells were collected from small...
متن کاملEffects of growth differentiation factor 9 on cell cycle regulators and ERK42/44 in human granulosa cell proliferation.
GDF-9 stimulates granulosa cell proliferation and plays important roles during folliclogenesis. However, its molecular mechanisms are still far from clear, particularly its roles in human granulosa cells around the periovulatory stage. Therefore, we investigated the effects of GDF-9 on cell cycle distribution, regulatory molecules, and signaling pathways involved in human luteinized granulosa (...
متن کاملRegulation of Proliferation and Steroidogenesis in Human Granulosa Cells
Background and Aims:Human follicles selected for further development are thought to receive precise signals from gonadotropins and locally produced growth factors for survival. In this experiment, the mechanisms of the regulation of proliferation and steroidogenesis by GDF-9 and Br-cAMP in human ovarian cells were investigated. Methods:SVOG cells were cultured and treated with GDF-9 and Br-cAMP...
متن کاملEffects of fenvalerate on steroidogenesis in cultured rat granulosa cells.
OBJECTIVE This study was designed to examine the in vitro effects of fenvalerate on steroid production and steroidogenic enzymes mRNA expression level in rat granulosa cells. METHODS Using primary cultured rat granulosa cells (rGCs) as model, fenvalerate of various concentrations (0, 1, 5, 25, 125, 625 micromol/L) was added to the medium for 24 h. In some cases, optimal concentrations of 22(R...
متن کاملGrowth differentiation factor-9 stimulates inhibin production and activates Smad2 in cultured rat granulosa cells.
Ovarian inhibin production is stimulated by FSH and several TGFbeta family ligands including activins and bone morphogenetic proteins. Growth differentiation factor-9 (GDF-9) derived by the oocyte is a member of the TGFbeta/activin family, and we have previously shown that GDF-9 treatment stimulates ovarian inhibin-alpha content in explants of neonatal ovaries. However, little is known about GD...
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ژورنال
عنوان ژورنال: Journal of Endocrinology
سال: 2006
ISSN: 0022-0795,1479-6805
DOI: 10.1677/joe.1.06503